Menu
Synergy in Action

16th Annual Scientific Meeting

19 – 21 February, 2020   //   Grand Hyatt, Washington DC

Distinguished Poster Award Recipient:

Up-Front Matching for Prospective Observational Studies to Mimic Randomization (Turkoz)  

All Poster PDFs and Abstracts are available at the end of the second day. 

 

 19 February 2020

   
 Welcome from the President Carla Canuso
slides slides
video
 
 Unresolved Problems in Neuroscience Drug Development    
  Drugs with abuse liability: Issues facing their use as treatments for psychiatric disorders and how to address them

Chair: Walter Dunn
slides slides
video
Discussants:
Jerry Sanacora
slides slides
video
Charles Nemeroff
slides slides
video
Raye Litten
slides
slides
 video
 
  Panel/Audience Discussion

video  
  Are current digital measures ready for prime time? Chair: Phil Harvey
Discussants:
Elektra Papadopoulos
slides slides
 video
Greg Strauss
slides slides
 video
Valentina Mantua*
 
  Panel/Audience Discussion video  

Wednesday Working Group Sessions 

   
  Artificial Intelligence (AI) and Machine Learning (ML) for CNS Clinical Trials Chairs:
Adam Butler
Larry Alphs
summary
 
  Autism Spectrum Disorder Chairs: 
Valentina Mantua
Tiffany Farchione
Celso Arango
summary
 
  Behavioral and Psychiatric Symptoms in Dementia—Agitation Subgroup Chairs:
Cedric O’Gorman
Paul Rosenberg
summary
 
  Developing Integrated Interventions: Clinical Trials for Drug/Neuromodulation-Psychotherapy Combinations Chairs:
Walter Dunn
Zimri Yaseen
summary
 
  Estimands and Missing Data Chairs:
Pilar Lim
Elena Polverejan
summary
 
  Prevention Trials in Alzheimer’s Disease Chairs:
Holly Posner
Phil Harvey
 

20 February 2020

 
Andrew C. Leon Distinguished Career Award Presentation Steve Marder
Carla Canuso
slides slides
Robert Heinssen
video
 
Enhancing drug development through artificial intelligence (AI) and machine learning (ML)  Chairs:
Adam Butler
Larry Alphs
Saeed Ahmed

 
  Introduction: Improving clinical trials with modern techniques Adam Butler
slides
slides
video
 
  What is artificial intelligence?

Saeed Ahmed
slides slides
video
 
  Applications of machine learning for psychiatry

Joe Geraci
slides slides
video
 
  Using AI/ML to differentiate drug and placebo responders in mood disorders: Offering the opportunity for enhanced patient selection Jane Tiller 
slides
slides
video
 
  AI-enabled digital phenotyping as a vehicle for clinical trial qualification and tracking of change during intervention Dennis Wall*
 
  Regulatory considerations when utilizing AI and ML applications in the design and execution of a CNS clinical trial David Millis
slides 
slides
video
 
  Panel Discussion Discussant:
Vikas Mohan Sharma

slides slides
video
 
  Summary    
The Brain – Gut Axis in Psychiatry and Neurology: Focus on the Microbiome Chairs: 
Jill Rasmussen
Ron Marcus
 
  Introduction Jill Rasmussen
slides
 slides
video
 
  Microbes, brain and behavior- Focus on depression  Ted Dinan
slides slides
video
 
  The brain immune gut axis- a big approach to developing new medications for psychiatric disorders in the new decade Robert Yolken
slides slides
video
 
  Microbiome and Alzheimer’s disease Miia Kivipelto
slides slides
video
 
  Microbiome and Parkinson disease: Therapeutic implications Peter LeWitt
slides slides
video
 
  Regulatory considerations for microbiome based therapeutics Paul Carlson
slides slides
video
Luca Pani
video
 
  Panel / Audience Discussion  Facilitator:
Ron Marcus
video
 
Is There a Fundamental Rethinking in the Way We Plan Clinical Trials? The Estimand Change in Mindset Chairs:
Pilar Lim
Michael Davis
Steve Brannan
 
  Introduction Pilar Lim
slides
slides
video
 
  Introduction to the ICH E9(R1) Addendum on “Estimands and Sensitivity Analysis in Clinical Trials”: A clinical perspective   Florence Butlen-Ducuing
slides slides
video
 
  Putting the ICH E9(R1) Guidance into practice – A multi-disciplinary collaboration  Elena Polverejan
slides slides
video
 
  Development of an estimand for acute treatment of Major Depressive Disorder trials: Keeping the new mindset in mind Zimri Yaseen
slides 
slides
video
 
  Regulatory implications of the ICH E9(R1) Guidance Robert Temple
slides slides
video
 
  Panel and Regulatory Discussion Facilitator:
Michael Davis
Panelists:
James Hung
Michael O’Kelly
Marc Walton
video
 
  Summary Michael Davis
 
 Poster Session/Reception Poster PDFs and Abstracts  

21 February 2020

 

Friday Working Group Sessions 

   
  Assessment Methods and Endpoints for Rapid-Acting Antidepressants-RAADs Chairs: 
Mark Opler
Elizabeth Ballard
Christian Yavorsky
summary
 
  Behavioral and Psychiatric Symptoms in Dementia—Apathy Subgroup Chairs: 
Krista Lanctôt
David Miller
summary
 
  Curriculum Development – Advanced CNS Clinical Trials Course Chairs:
Carla Canuso
Kari Nations
summary
 
  Innovative Technologies for Clinical Trials  Chairs:
Richard Keefe
Michael Davis
summary
 
  Orphan Diseases Chairs:
Joan Busner
Gahan Pandina
Ravi Anand
summary
 
Role of Reward Processing Assessment as a Tool in Drug Development Chairs:
Larry Ereshefsky
Raimund Buller         
 
  Introduction Raimund Buller
Larry Ereshefsky
video
 
  The neurobiology of anhedonia: Circuitry and relevance to drug development and patient stratification Diego Pizzagalli
slides slides
video
 
  Reward processing mechanisms underlying negative symptoms in schizophrenia Gregory Strauss
slides slides
video
 
  Reward processing in neurological disorders: Focus on Parkinson’s disease Masud Husain
slides slides
video
 
  Pragmatic aspects of including reward processing tasks in drug development trials Stephane Pollentier
slides slides  
 
video
 
  Comment: Translational considerations – NIMH Sarah Lisanby
slides slides
 video
 
  Regulatory view on use of reward processing in patient segmentation and as a marker for treatment response Tiffany Farchione
slides slides
 video
 
  Panel / Audience Discussion video  
  Summary    
  Meeting Adjourned

*Slides not released

Ramy Mahmoud
video