2024 Autumn Conference
12 – 13 September, 2024 // San Diego, CA
Distinguished Poster Award Recipients:
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Hopkins – A clinical trial inclusion criteria to enrich for patients presenting with canonical symptom structure in bipolar depression (Abstract) Horan – Longitudinal convergence of dispersed clinical ratings and ecological momentary assessment burst assessments of negative symptoms in schizophrenia (Abstract) |
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All Poster PDFs and Abstracts are available here. |
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12 September 2024 |
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| Welcome from the President | Luca Pani slides video |
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| Use of Neurophysiological Markers to Design and Enrich Clinical Trials in Rare Neurological Diseases | Chairs: Kemi Olugemo Uma Vaidyanathan |
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| Introduction
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Kemi Olugemo slides video |
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| The parents’ journey through drug development: Making the impossible possible for Angelman Syndrome | Allyson Berent slides video |
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| EEG as a marker of direct mouse-to-human translation in clinical trials in neurodevelopmental disorders | Elizabeth Berry-Kravis slides video |
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| Beyond PSG: Sleep assessment endpoints, considerations and recommendations | Justin Brooks slides video |
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| Computational approaches to unlocking EEG and PSG as biomarkers in NDDs | David Matthews slides video |
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| Summary | Uma Vaidyanathan slides video |
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| Panel Discussion | Facilitators: Kemi Olugemo Uma Vaidyanathan video |
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Use of Neurophysiological Markers to Design and Enrich Clinical Trials in Psychiatric Disorders |
Chairs: Atul Mahableshwarkar Jenicka Engler |
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| Introduction | Atul Mahableshwarkar slides video |
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| Biomarker Driven RCTs for Mood and Anxiety Disorders: Has the Time Arrived? | Manish Jha slides video |
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| Can biomarker enrichment improve clinical outcome in PoC clinical trials for autism spectrum disorder? | Gahan Pandina slides video |
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| Discovery, validation and implementation of neurocognitive patient selection markers in drug development for depression | Adam Savitz slides video |
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| Regulatory considerations on the opportunities and challenges of neurophysiological markers | Luca Pani slides video |
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| Panel Discussion | Facilitator: Jenicka Engler video |
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Thursday Working Group Sessions |
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| Development of Novel Endpoints for Clinical Trials in Substance Use Disorders Working Group | Chairs: Tanya Ramey Martin Mumenthaler slidessummary |
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| Orphan Diseases Working Group | Chairs: Joan Busner Gahan Pandina slides |
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| Methodological Issues in Study Designs for Clinical Trials with Psychedelics Working Group | Chairs: Amir Inamdar Joyce Tsai summary |
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| Poster Session/Reception | Poster PDFs and Abstracts | ||
13 September 2024 |
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| Friday Working Group Sessions | |||
| Accelerating Development of Psychopathology Measures – ISCTM/ECNP Joint Working Group | Chairs: Nina Schooler Jenicka Engler Celso Arango slidessummary |
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| Diversity in CNS Clinical Trials Working Group | Chairs: Siân Ratcliffe Abhishek Pratap slides |
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| Sleep Methodology in CNS Trials Working Group | Chairs: Margaret Moline Georg Dorffner slidessummary |
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| How to Conduct Trials that Enroll Suicidal Patients | Chairs: Samuel Wilkinson Jill Harkavy-Friedman |
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| Introduction | Samuel Wilkinson slides video |
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| Choosing the right design and analytic approach for trials recruiting patients at risk for suicide | Larry Alphs slides video |
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| Designing and implementing studies in adult and adolescent patients with MDD at imminent risk for suicide | Dong-Jing (DJ) Fu slides video |
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| Practical experiences related to an NIMH-funded clinical trial of ketamine in adolescents with major depression and suicidality | Michael Bloch slides video |
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| Considerations on choosing the appropriate setting from which to enroll patients | Gerard Sanacora slides video |
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| Suicidal ideations and behaviors: Regulatory perspectives | Zimri Yaseen slides video |
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| Panel Discussion
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Facilitator: Jill Harkavy-Friedman video |
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| Decisions, decisions, decisions: How planning and conduct of RCTs influence outcomes | Chairs: Nina Schooler Stephen Brannan |
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| Introduction | Nina Schooler slides video |
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| Trying to find balance between speed, cost, and quality | Stephen Brannan slides Seth Hopkins slides video |
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| The journey balancing science and operations during protocol development: Case studies and examples | Emilio Neto Jane Twitchen slides video |
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| Impact of protocol decisions and modifications in RCT conduct | Steve Szabo slides Gerard Sanacora slides video |
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| Perspectives on protocol decisions and modifications from independent and academic site leaders | Dawn Velligan slides David Walling slides video |
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| Panel Discussion | Facilitators: Nina Schooler Stephen Brannan video |
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| Meeting Adjourned | Luca Pani slides video |
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