18th Annual Scientific Meeting
23 – 25 February, 2022 // Grand Hyatt, Washington DC
Distinguished Poster Award Recipients:
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Depression ClinRO inference using momentary multimodal behavioral and physiological digital biomarkers from decentralized data collection (abstract) – Cicconet Characterizing depressive symptom fluctuations using automated speech assessment: a remote feasibility study (abstract) – DeSouza |
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All Poster PDFs and Abstracts are available here. |
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23 February 2022 |
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| Welcome from the President | Ramy Mahmoud slides video |
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| Unresolved Passive sensing and active data collection in clinical trials: Filling the gaps between efficacy and effectiveness | Chairs: Shaheen Lakhan John Docherty |
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| Salutation and session intro
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Shaheen Lakhan slides video |
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| Leveraging passive sensing in pharma clinical development trials | Sean Kenny* video |
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| Passive sensing and smartphone-based tracking in clinical trials for migraine | Mia Minen slides video |
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| Methodological considerations for passive sensing and smartphone-based tracking | Jessica Lipschitz slides video |
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| Leveraging Ecological Momentary Assessment to improve treatment outcomes in clinical trials | Cassandra Snipes slides video |
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| Panel Discussion | Facilitators: Shaheen Lakhan John Docherty Panelists: Elizabeth Kunkoski Lorenzo Guizzaro slides video |
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Wednesday Working Group Sessions |
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| Algorithms/Flags to Identify Clinical Inconsistency in the Use of Rating Scales In CNS RCTs Working Group | Chairs: Jonathan Rabinowitz Nina Schooler summary |
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| Assessment Methods and Endpoints for Psychedelics and Rapid-Acting Antidepressants – RAADs Working Group | Chairs: Christian Yavorsky Jan Sedway |
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| Innovative Technologies for CNS Clinical Trials Working Group | Chairs: Richard Keefe Mike Davis summary |
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| Orphan Diseases Working Group | Chairs: Joan Busner Gahan Pandina summary |
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24 February 2022 |
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| Lewis Alan Opler Prize Presentation | Carla Canuso slides Amy Pinkham slides video |
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| Decentralized clinical trials in CNS: What have we learnt, what might the future look like? | Chairs: Amir Kalali Eric Lenze |
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| Decentralized trials: Definitions, myths and the way forward | Amir Kalali slides video |
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| An example of an academic study conducted remotely: Lessons learnt | Eric Lenze slides video |
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| An example of a clinical trial conducted during the pandemic: Lessons learnt | Debra Phillips* |
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| Pivoting to remote assessment of cognition during COVID-19 and beyond | Alexandra Atkins slides video |
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| Impact of remote assessments during the COVID pandemic: Lessons learnt | Alan Kott slides video |
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| Panel Discussion | Facilitator: Amir Kalali video |
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| Summary | |||
| Methodological issues of measuring sleep in CNS trials | Chairs: William Jacobson Georg Dorffner Adam Savitz |
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| Consequences of impaired sleep and wakefulness – importance of considering and means to address in trials | William Jacobson slides video |
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| Objective and subjective measurement of sleep in clinical trials | Adam Savitz slides video |
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| Proper validation of measurement tools against the gold standard | Georg Dorffner slides video |
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| Measuring sleep quality | Andrew Krystal slides video |
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| Experience with measuring sleep in circadian-rhythms sleep disorder targeted trials | Margaret Moline* slides |
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| Regulatory considerations | Valentina Mantua slides David Reasner Maria Tome video |
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| Panel / Audience Discussion
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Facilitator: William Jacobson video |
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| The changing site landscape and the potential impacts on trial methodology | Chairs: Colin Sauder Michael Liebowitz |
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| Introduction | Colin Sauder slides video |
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| Participant retention and study burden: A worthy subject | Elan Cohen slides video |
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| Wherefore art thou study participant? | Jenicka Engler slides video |
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| Consolidation, industrialization & potential downsides (or CNS drug development & its discontents) | Mark Opler slides video |
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| Increasing scrutiny of rater performance: Is it worth it? | David Daniel slides video |
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| Regional scoring differences observed in clinical trials | Steven Targum slides video |
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| Selecting quality sites during the great pandemic power shift | Alexandria Wise slides video |
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| Panel Discussion | Discussant: Michael Liebowitz slides video |
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| Poster Session/Reception | Poster PDFs and Abstracts | ||
25 February 2022
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Friday Working Group Sessions |
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| Behavioral and Psychiatric Symptoms in Dementia—Apathy Working Group | Chairs: Krista Lanctôt David Miller summary |
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| Digital Biomarkers Working Group | Chairs: Adam Butler Vikas Sharma summary |
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| COVID-19 CNS Clinical Trials Methodologies Blueprint – ISCTM/ECNP Joint Working Group | Chairs: Dragana Bugarski-Kirola Kemi Olugemo Gerard Dawson summary |
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| Estimands and Missing Data Working Group | Chairs: Elena Polverejan Pilar Lim summary |
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| Use of Artificial Intelligence/Machine Learning (AI/ML) to improve efficiency of drug development process | Chairs: Larry Alphs Joseph Geraci |
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| Introduction | Larry Alphs slides video |
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| A neo-biotech: Scaling the largest and most therapeutically diverse pipeline in the industry | Naheed Kurji slides video |
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| Machine learning strategies to track brain and behavioral state changes during DBS treatment for depression | Helen Mayberg slides video |
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| Next generation machine intelligence for drug development & clinical trial failure reduction | Joseph Geraci slides video |
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| Transforming research in mental health via big data and machine learning | James Kennedy slides video |
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| AI/ML response prediction for antidepressant treatment: Clinician perspective | Raymond Lam slides video |
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| Funding computational psychiatry | Michele Ferrante slides video |
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| Regulation in the age of exponential innovations: Artificial intelligence | Khair ElZarrad slides video |
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| Panel / Audience Discussion | Facilitator: Larry Alphs video |
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| Summary | |||
| Meeting Adjourned
*Slides and/or video not released |
Gary Sachs video |
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