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Synergy in Action

10th Annual Scientific Meeting

plus 2014 ISCTM Mental Health Research-to-Policy Forum
18 – 20 February, 2014   //   Washington DC, USA

Poster Awardee:

The Utility of a Novel Cognitive Paradigm for Identifying and Tracking Subjects at High Risk for Early Alzheimer’s Dementia: Implications for Clinical Trials (Curiel R)
All Poster Abstracts are available at the end of the second day

Day 1 (18 February 2014)

Presidential Welcome
ISCTM 10th Anniversary Tribute
R Keefe
slides slides
L Alphs
slides slides
G Garibaldi
slides slides
R Keefe
slides slides
video
Developing Treatments for Schizophrenia in the 21st Century: Preventing Disease Progression ~ A Novel Paradigm for Research Chairs:
R Anand
G Haig
L Alphs
  Overview of Session G Haig*
video
  Disease Modification in Schizophrenia: Overview of the Issues R Anand
slides slides
video
  Clinical Course of Schizophrenia: Implications for Therapeutic Intervention and Disease Modification/Discussion J Lieberman
slides
slides
video
  Defining, Measuring and Tracking Disease Modification in Schizophrenia/Discussion S Kapur
slides
slides
video
  Neurodevelopmental Course of Schizophrenia and Specific Therapeutic Strategies for Developing Treatments for Preventing Disease Progression in Schizophrenia/Discussion H Meltzer
slides
slides
video
  Identifying and Addressing Regulatory Challenges to Disease Modification in Schizophrenia/Discussion B Levin
slides
slides
T Laughren*
video (Levin/Laughren)
  Panel and Audience Discussion Facilitator:
S Marder
slides slides
video
W Carpenter
R Heinssen
S Kapur
J Lieberman
H Meltzer
L Pani
  Session Summary R Anand*
video

Working Group Dinners

 
  Adaptive Design Chair:
Haynes
Working Group
slides
slides
Report Back
slides
slides
  Addressing Methodological Challenges in International CNS Clinical Trials Chairs:
Keefe
Kalali
Report Back

slides slides
  Assessing Abuse Liability Potential Chairs:
Sokolowska
Klein
Setnik
Working Group Slides:
Klein, Calderon,
Schoedel, Sokolowska, Setnik
Report
Back
slides slides
  Biomarkers – Minimum Standards Initiative Chairs:
Potkin
Goff
Report Back

slides slides
  Cognitive Assessment in Alzheimer’s Disease and its Precursors Chairs:
Posner
Harvey
Report Back

slides slides
  Implementing Innovations in CNS Clinical Trials Chairs:
Sachs
Detke

Report Back
slides slides

Day 2 (19 February 2014)

2014 ISCTM National Mental Health Research-to-Policy Forum: Revitalizing Academia-Industry Collaboration in Psychiatry Treatment Research Chairs:
R Ferziger
R Manderscheid
  Session Goals and Speaker Introductions R Ferziger
slides
slides
video
R Manderscheid*
  Current Status/Goals/Needs/Challenges

  • Academic View
  • Industry View
  • Health Policy View
J Lieberman*
video
F Lewis-Hall
slides
slides
(
not yet released)
R Frank**
video
  Panel and Audience Discussion: Response and Next Steps E Szabo
K Thompson
J Lieberman
F Lewis-Hall
R Frank
video
  Case Presentation
Panel and Discussion

Moderator:
H Goldman*
video (includes closing comments)

  Closing Comments/Paths Forward J Lieberman
F Lewis-Hall
R Frank
H Goldman

Parallel Sessions

 
Session A: Dementia Study Designs, Methodologies and Regulatory Perspectives – One Size Does Not Fit All! Chairs:
P Tariot
J Rasmussen
  Defining the Problem and Session Overview J Rasmussen
slides slides
video
  20 Years of Clinical Trials in Alzheimer’s Disease: Some Lessons Learned P Tariot
slides slides
video
  Pathobiological Targets in AD Trials: Where We Have Been and Where We’re Headed M Jefson
slides slides
video
  Clinical Trial in Frontotemporal Lobar Degeneration: Focus on Tau/Discussion A Boxer
slides slides
video
  Designs of Clinical Trials in DLB and PDD/Discussion I McKeith
slides slides
video
  Regulatory Challenges Across Dementia Subtypes

  • European View
  • FDA View
M Haberkamp
slides
slides
video
N Kozauer
slides slides
  Panel Discussion/Summary video (Kozauer and panel)
Session B: Taking Personalized Medicine Seriously – Biomarker Approaches in Phase llb/lll Studies in Major Depression and Schizophrenia Chairs:
H Murck
T Laughren
  Introduction H Murck
slides slides
video
  Regulatory Issues in the Use of Biomarkers in Phase llb/lll Studies in Depression and Schizophrenia T Laughren
slides slides
video
  Biological Differentiation of Depression Subtypes: Cortisol, Inflammatory Markers, Proteomics and Course/Discussion F Lamers***
slides slides
  Physiological Sensor Technology for Objective Clinical Data in Psychiatry/Discussion R Picard
slides slides
video (video referenced in presentation not released)
  Target Based Biomarker Selection – Mineralocorticoid Receptor Related Biomarkers and Treatment Outcome in Depression/Discussion H Murck
slides slides
video
  Actigraphic Monitoring of Physical Activity in Clinical Trials in Schizophrenia/Discussion S Walther
slides slides
video
  The Use of Biomarkers in Clinical Trials in Schizophrenia D Goff
slides slides
video
  Industry Perspective/Panel Discussion J Wendland
slides slides
All Speakers
video (includes Wendland and Laughren summary)
  Summary Comments T Laughren*
  Poster Session / Reception Poster Abstracts

Day 3 (20 February 2014)

Presentation of the Andrew C. Leon Distinguished Career Award S Romano
L Alphs
slides
slides
video
Innovations in Clinical Trials: Opportunities for Research Using Practice-Based Networks Chairs:
J Severe
R Heinssen
  Introduction J Severe
slides slides
video
  New Research Platforms Are Needed to Speed Development and Deployment of CNS Interventions R Heinssen
slides slides
video
  The Necessity for Practice-Based Research Networks: Making it Work at the National Heart Lung and Blood Institute/Discussion M Lauer
slides slides
video
  The Mental Health Research Network: Practical Experience Using Health Care Plan Networks/Discussion G Simon
slides slides
video
  Practice-Based Research Networks: How Can They Help Patients and Industry?/Discussion R Dubois
slides slides
video
  Methodological and Statistical Issues in Designing RCTs on Practice-Based Networks/Discussion H Kraemer
slides slides
video
  Discussion Panel T Laughren*
All Speakers
video
Domain-Based Approaches to Pathology in the Development of Novel Psychiatric Therapies: Enhancing Tractability in Discovery and Trial Methodology Chairs:
R Keefe
G Garibaldi
  Introduction R Keefe
slides slides
video
  Cross Diagnostic Disorders of Cognition/Motivation, the Why and the What G Garibaldi
slides slides
video
  Neurocircuitry of Motivation and Cognition in Animal Models/Discussion J Salamone
slides slides
video
  Neurocircuitry of Impulsivity and Motivation in Psychiatric Disorders/Discussion S Potkin
slides slides
video
  Mapping Cognitive and Motivational Domains Across Levels of Analysis: Challenges for Target Specification/Discussion R Bilder
slides slides
video
  Focused Panel Discussion R Heinssen
L Kempf
T Laughren
L Pani
video
Meeting Adjourns S Romano
video
* No slides presented
** Slides not released
*** Video not released