10th Annual Scientific Meeting
plus 2014 ISCTM Mental Health Research-to-Policy Forum
18 – 20 February, 2014 // Washington DC, USA
Poster Awardee: |
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The Utility of a Novel Cognitive Paradigm for Identifying and Tracking Subjects at High Risk for Early Alzheimer’s Dementia: Implications for Clinical Trials (Curiel R) | ||
All Poster Abstracts are available at the end of the second day |
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Day 1 (18 February 2014) |
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Presidential Welcome ISCTM 10th Anniversary Tribute |
R Keefe![]() L Alphs ![]() G Garibaldi ![]() R Keefe ![]() ![]() |
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Developing Treatments for Schizophrenia in the 21st Century: Preventing Disease Progression ~ A Novel Paradigm for Research | Chairs: R Anand G Haig L Alphs |
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Overview of Session | G Haig*![]() |
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Disease Modification in Schizophrenia: Overview of the Issues | R Anand![]() ![]() |
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Clinical Course of Schizophrenia: Implications for Therapeutic Intervention and Disease Modification/Discussion | J Lieberman![]() ![]() |
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Defining, Measuring and Tracking Disease Modification in Schizophrenia/Discussion | S Kapur![]() ![]() |
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Neurodevelopmental Course of Schizophrenia and Specific Therapeutic Strategies for Developing Treatments for Preventing Disease Progression in Schizophrenia/Discussion | H Meltzer![]() ![]() |
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Identifying and Addressing Regulatory Challenges to Disease Modification in Schizophrenia/Discussion | B Levin![]() T Laughren* ![]() |
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Panel and Audience Discussion | Facilitator: S Marder ![]() ![]() W Carpenter R Heinssen S Kapur J Lieberman H Meltzer L Pani |
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Session Summary | R Anand*![]() |
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Working Group Dinners |
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Adaptive Design | Chair: Haynes Working Group ![]() Report Back ![]() |
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Addressing Methodological Challenges in International CNS Clinical Trials | Chairs: Keefe Kalali Report Back ![]() |
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Assessing Abuse Liability Potential | Chairs: Sokolowska Klein Setnik Working Group Slides: Klein, Calderon, Schoedel, Sokolowska, Setnik Report Back ![]() |
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Biomarkers – Minimum Standards Initiative | Chairs: Potkin Goff Report Back ![]() |
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Cognitive Assessment in Alzheimer’s Disease and its Precursors | Chairs: Posner Harvey Report Back ![]() |
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Implementing Innovations in CNS Clinical Trials | Chairs: Sachs Detke Report Back ![]() |
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Day 2 (19 February 2014) |
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2014 ISCTM National Mental Health Research-to-Policy Forum: Revitalizing Academia-Industry Collaboration in Psychiatry Treatment Research | Chairs: R Ferziger R Manderscheid |
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Session Goals and Speaker Introductions | R Ferziger![]() ![]() R Manderscheid* |
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Current Status/Goals/Needs/Challenges
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J Lieberman*![]() F Lewis-Hall ![]() ![]() R Frank** ![]() |
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Panel and Audience Discussion: Response and Next Steps | E Szabo K Thompson J Lieberman F Lewis-Hall R Frank ![]() |
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Case Presentation Panel and Discussion |
Moderator: |
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Closing Comments/Paths Forward | J Lieberman F Lewis-Hall R Frank H Goldman |
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Parallel Sessions |
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Session A: Dementia Study Designs, Methodologies and Regulatory Perspectives – One Size Does Not Fit All! | Chairs: P Tariot J Rasmussen |
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Defining the Problem and Session Overview | J Rasmussen![]() ![]() |
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20 Years of Clinical Trials in Alzheimer’s Disease: Some Lessons Learned | P Tariot![]() ![]() |
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Pathobiological Targets in AD Trials: Where We Have Been and Where We’re Headed | M Jefson![]() ![]() |
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Clinical Trial in Frontotemporal Lobar Degeneration: Focus on Tau/Discussion | A Boxer![]() ![]() |
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Designs of Clinical Trials in DLB and PDD/Discussion | I McKeith![]() ![]() |
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Regulatory Challenges Across Dementia Subtypes
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M Haberkamp![]() ![]() N Kozauer ![]() |
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Panel Discussion/Summary | ![]() |
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Session B: Taking Personalized Medicine Seriously – Biomarker Approaches in Phase llb/lll Studies in Major Depression and Schizophrenia | Chairs: H Murck T Laughren |
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Introduction | H Murck![]() ![]() |
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Regulatory Issues in the Use of Biomarkers in Phase llb/lll Studies in Depression and Schizophrenia | T Laughren![]() ![]() |
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Biological Differentiation of Depression Subtypes: Cortisol, Inflammatory Markers, Proteomics and Course/Discussion | F Lamers***![]() |
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Physiological Sensor Technology for Objective Clinical Data in Psychiatry/Discussion | R Picard![]() ![]() |
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Target Based Biomarker Selection – Mineralocorticoid Receptor Related Biomarkers and Treatment Outcome in Depression/Discussion | H Murck![]() ![]() |
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Actigraphic Monitoring of Physical Activity in Clinical Trials in Schizophrenia/Discussion | S Walther![]() ![]() |
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The Use of Biomarkers in Clinical Trials in Schizophrenia | D Goff![]() ![]() |
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Industry Perspective/Panel Discussion | J Wendland![]() All Speakers ![]() |
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Summary Comments | T Laughren* | |
Poster Session / Reception | Poster Abstracts | |
Day 3 (20 February 2014) |
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Presentation of the Andrew C. Leon Distinguished Career Award | S Romano L Alphs ![]() ![]() |
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Innovations in Clinical Trials: Opportunities for Research Using Practice-Based Networks | Chairs: J Severe R Heinssen |
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Introduction | J Severe![]() ![]() |
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New Research Platforms Are Needed to Speed Development and Deployment of CNS Interventions | R Heinssen![]() ![]() |
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The Necessity for Practice-Based Research Networks: Making it Work at the National Heart Lung and Blood Institute/Discussion | M Lauer![]() ![]() |
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The Mental Health Research Network: Practical Experience Using Health Care Plan Networks/Discussion | G Simon![]() ![]() |
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Practice-Based Research Networks: How Can They Help Patients and Industry?/Discussion | R Dubois![]() ![]() |
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Methodological and Statistical Issues in Designing RCTs on Practice-Based Networks/Discussion | H Kraemer![]() ![]() |
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Discussion Panel | T Laughren* All Speakers ![]() |
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Domain-Based Approaches to Pathology in the Development of Novel Psychiatric Therapies: Enhancing Tractability in Discovery and Trial Methodology | Chairs: R Keefe G Garibaldi |
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Introduction | R Keefe![]() ![]() |
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Cross Diagnostic Disorders of Cognition/Motivation, the Why and the What | G Garibaldi![]() ![]() |
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Neurocircuitry of Motivation and Cognition in Animal Models/Discussion | J Salamone![]() ![]() |
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Neurocircuitry of Impulsivity and Motivation in Psychiatric Disorders/Discussion | S Potkin![]() ![]() |
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Mapping Cognitive and Motivational Domains Across Levels of Analysis: Challenges for Target Specification/Discussion | R Bilder![]() ![]() |
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Focused Panel Discussion | R Heinssen L Kempf T Laughren L Pani ![]() |
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Meeting Adjourns | S Romano![]() |
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* No slides presented ** Slides not released *** Video not released |