10th Annual Scientific Meeting
plus 2014 ISCTM Mental Health Research-to-Policy Forum
18 – 20 February, 2014 // Washington DC, USA
Poster Awardee: |
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| The Utility of a Novel Cognitive Paradigm for Identifying and Tracking Subjects at High Risk for Early Alzheimer’s Dementia: Implications for Clinical Trials (Curiel R) | ||
| All Poster Abstracts are available at the end of the second day |
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Day 1 (18 February 2014) |
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| Presidential Welcome ISCTM 10th Anniversary Tribute |
R Keefe slidesL Alphs slidesG Garibaldi slidesR Keefe slides video |
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| Developing Treatments for Schizophrenia in the 21st Century: Preventing Disease Progression ~ A Novel Paradigm for Research | Chairs: R Anand G Haig L Alphs |
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| Overview of Session | G Haig* video |
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| Disease Modification in Schizophrenia: Overview of the Issues | R Anand slides video |
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| Clinical Course of Schizophrenia: Implications for Therapeutic Intervention and Disease Modification/Discussion | J Lieberman slides video |
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| Defining, Measuring and Tracking Disease Modification in Schizophrenia/Discussion | S Kapur slides video |
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| Neurodevelopmental Course of Schizophrenia and Specific Therapeutic Strategies for Developing Treatments for Preventing Disease Progression in Schizophrenia/Discussion | H Meltzer slides video |
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| Identifying and Addressing Regulatory Challenges to Disease Modification in Schizophrenia/Discussion | B Levin slides T Laughren* video (Levin/Laughren) |
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| Panel and Audience Discussion | Facilitator: S Marder slides videoW Carpenter R Heinssen S Kapur J Lieberman H Meltzer L Pani |
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| Session Summary | R Anand* video |
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Working Group Dinners |
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| Adaptive Design | Chair: Haynes Working Group slidesReport Back slides |
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| Addressing Methodological Challenges in International CNS Clinical Trials | Chairs: Keefe Kalali Report Back slides |
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| Assessing Abuse Liability Potential | Chairs: Sokolowska Klein Setnik Working Group Slides: Klein, Calderon, Schoedel, Sokolowska, Setnik Report Back slides |
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| Biomarkers – Minimum Standards Initiative | Chairs: Potkin Goff Report Back slides |
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| Cognitive Assessment in Alzheimer’s Disease and its Precursors | Chairs: Posner Harvey Report Back slides |
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| Implementing Innovations in CNS Clinical Trials | Chairs: Sachs Detke Report Back slides |
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Day 2 (19 February 2014) |
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| 2014 ISCTM National Mental Health Research-to-Policy Forum: Revitalizing Academia-Industry Collaboration in Psychiatry Treatment Research | Chairs: R Ferziger R Manderscheid |
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| Session Goals and Speaker Introductions | R Ferziger slides video R Manderscheid* |
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Current Status/Goals/Needs/Challenges
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J Lieberman* video F Lewis-Hall slides (not yet released)R Frank** video |
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| Panel and Audience Discussion: Response and Next Steps | E Szabo K Thompson J Lieberman F Lewis-Hall R Frank video |
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| Case Presentation Panel and Discussion |
Moderator: |
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| Closing Comments/Paths Forward | J Lieberman F Lewis-Hall R Frank H Goldman |
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Parallel Sessions |
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| Session A: Dementia Study Designs, Methodologies and Regulatory Perspectives – One Size Does Not Fit All! | Chairs: P Tariot J Rasmussen |
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| Defining the Problem and Session Overview | J Rasmussen slides video |
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| 20 Years of Clinical Trials in Alzheimer’s Disease: Some Lessons Learned | P Tariot slides video |
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| Pathobiological Targets in AD Trials: Where We Have Been and Where We’re Headed | M Jefson slides video |
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| Clinical Trial in Frontotemporal Lobar Degeneration: Focus on Tau/Discussion | A Boxer slides video |
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| Designs of Clinical Trials in DLB and PDD/Discussion | I McKeith slides video |
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Regulatory Challenges Across Dementia Subtypes
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M Haberkamp slides video N Kozauer slides |
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| Panel Discussion/Summary | video (Kozauer and panel) |
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| Session B: Taking Personalized Medicine Seriously – Biomarker Approaches in Phase llb/lll Studies in Major Depression and Schizophrenia | Chairs: H Murck T Laughren |
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| Introduction | H Murck slides video |
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| Regulatory Issues in the Use of Biomarkers in Phase llb/lll Studies in Depression and Schizophrenia | T Laughren slides video |
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| Biological Differentiation of Depression Subtypes: Cortisol, Inflammatory Markers, Proteomics and Course/Discussion | F Lamers*** slides |
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| Physiological Sensor Technology for Objective Clinical Data in Psychiatry/Discussion | R Picard slides video (video referenced in presentation not released) |
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| Target Based Biomarker Selection – Mineralocorticoid Receptor Related Biomarkers and Treatment Outcome in Depression/Discussion | H Murck slides video |
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| Actigraphic Monitoring of Physical Activity in Clinical Trials in Schizophrenia/Discussion | S Walther slides video |
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| The Use of Biomarkers in Clinical Trials in Schizophrenia | D Goff slides video |
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| Industry Perspective/Panel Discussion | J Wendland slides All Speakers video (includes Wendland and Laughren summary) |
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| Summary Comments | T Laughren* | |
| Poster Session / Reception | Poster Abstracts | |
Day 3 (20 February 2014) |
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| Presentation of the Andrew C. Leon Distinguished Career Award | S Romano L Alphs slides video |
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| Innovations in Clinical Trials: Opportunities for Research Using Practice-Based Networks | Chairs: J Severe R Heinssen |
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| Introduction | J Severe slides video |
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| New Research Platforms Are Needed to Speed Development and Deployment of CNS Interventions | R Heinssen slides video |
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| The Necessity for Practice-Based Research Networks: Making it Work at the National Heart Lung and Blood Institute/Discussion | M Lauer slides video |
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| The Mental Health Research Network: Practical Experience Using Health Care Plan Networks/Discussion | G Simon slides video |
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| Practice-Based Research Networks: How Can They Help Patients and Industry?/Discussion | R Dubois slides video |
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| Methodological and Statistical Issues in Designing RCTs on Practice-Based Networks/Discussion | H Kraemer slides video |
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| Discussion Panel | T Laughren* All Speakers video |
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| Domain-Based Approaches to Pathology in the Development of Novel Psychiatric Therapies: Enhancing Tractability in Discovery and Trial Methodology | Chairs: R Keefe G Garibaldi |
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| Introduction | R Keefe slides video |
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| Cross Diagnostic Disorders of Cognition/Motivation, the Why and the What | G Garibaldi slides video |
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| Neurocircuitry of Motivation and Cognition in Animal Models/Discussion | J Salamone slides video |
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| Neurocircuitry of Impulsivity and Motivation in Psychiatric Disorders/Discussion | S Potkin slides video |
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| Mapping Cognitive and Motivational Domains Across Levels of Analysis: Challenges for Target Specification/Discussion | R Bilder slides video |
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| Focused Panel Discussion | R Heinssen L Kempf T Laughren L Pani video |
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| Meeting Adjourns | S Romano video |
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| * No slides presented ** Slides not released *** Video not released |
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