Menu
Synergy in Action

Publications

Consistency checks to improve measurement with the Positive and Negative Syndrome Scale (PANSS)

Jonathan Rabinowitz , Nina R Schooler, Ariana Anderson, Lindsay Ayearst, David Daniel, Michael Davidson, Anzalee Khan, Bruce Kinon, Francois Menard, Lewis Opler, Mark Opler, Joanne B Severe, David Williamson, Christian Yavorsky, Jun Zhao, ISCTM ALGORITHMS/FLAGS TO IDENTIFY CLINICAL INCONSISTENCY IN THE USE OF RATING SCALES IN CNS RCTs working group members
Schizophrenia Research article/S0920-9964(17)30141 (Open Access)
International Society for CNS Clinical Trials and Methodology convened an expert working-group that assembled consistency/inconsistency flags for the Positive and Negative Syndrome Scale (PANSS). Twenty-four flags were identified and divided based on extent to which they represent error (Possibly, Probably, Very probably or definitely). The flags were applied to assessments derived from the NEWMEDS data repository and the CATIE clinical trial data. Almost 40% of ratings had at least one inconsistency flag raised and 10% had two. Application of flags to clinical rating can improve reliability and validity of trials.
Click here to view full publication
« Return to Publications Page