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Consistency checks to improve measurement with the Montgomery-Asberg Depression Rating Scale (MADRS)

Jonathan Rabinowitz , Nina R. Schooler, Brianne Brown, Mads Dalsgaard, Nina Engelhardt, Gretchen Friedberger, Bruce J. Kinon, Daniel Lee, Felice Ockun, Atul Mahableshwarkar, Joyce Tsai, Janet B.W. Williams, Colin Sauder, Christian Yavorsky, ISCTM ALGORITHMS/FLAGS TO IDENTIFY CLINICAL INCONSISTENCY IN THE USE OF RATING SCALES IN CNS RCTs working group members
Journal of Affective Disorders article/S0165032718332105 (open access)
International Society for CNS Clinical Trials and Methodology convened an expert Working Group that assembled consistency/inconsistency flags for the Montgomery-Asberg Depression Rating Scale (MADRS). Twenty-two flags were identified. Seven flags are believed to be strong flags that suggest that a thorough review of rating is warranted. The flags were applied to assessments derived from the NEWMEDS data repository. Almost 65% of ratings had at least one inconsistency flag raised and 22% had two or more. Application of flags to clinical ratings may improve reliability of ratings and validity of trials.
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