Forming and Utilizing Integrated Clinical Trials Databases to Advance Insights in Treatments for Cognition in Schizophrenia and Alzheimer’s Disease

Chairs: Joanne Severe, Larry Alphs, Ginger Haynes

The purpose of the integration (or combining) of datasets from distinct clinical trials within an area of study is to be able to conduct “mega analyses” using individual subject-level data across studies, as compared to “meta analyses” which combine the results of analyses from individual studies. This methodology can be a powerful tool as integrated datasets will be larger and potentially more heterogeneous than any single dataset, providing opportunities to explore in-depth “signals” found in individual studies as well as the modeling of subgroups which are not adequately powered in smaller databases. This session will address the challenges in constructing and using such databases utilizing examples from RCTs in schizophrenia and Alzheimer’s Disease, and a discussion of statistical issues.
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