Bibliography on Mitochondria/Mitochondrial Function (relative to CNS/Mental Disorders, Dementia, and Aging)

Alexeyev MF, LEDoux SP and Wilson GL. Mitochondrial DNA and aging. Clin Sci (Lond). 2004 Oct;107(4):355-64
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/15279618
DNA, RNA, aging, oxidative phosphorylation

Andreopoulos et al. Lithium & Valproate restore glutamate-glutamine ratios and Ca homeostasis. Pharmacogenom J. 4:365, 2004
Abstract: http://www.nature.com/tpj/journal/v4/n6/abs/6500266a.html
Calcium, glutamate, lithium, vaproic acid

Berk M,Kapczinski F, Andreazza AC, Dean OM, Giorlando F, Maes M, Yücel M, Gama CS, Dodd S, Dean B, Magalhães PVS, Amminger P, McGorry P, Malhi GS:Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors. Neurosci Biobehav Rev. 2011 Jan;35(3):804-17. Epub 2010 Oct 8.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20934453
Bipolar disorder, oxidative stress

Bishop NA, Lu T, Yankner BA: Neural mechanisms of ageing and cognitive decline. Nature 2010 Mar 25;464(7288):529-35.
Free Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927852/
Aging, cognitive decline

Brandon NJ,Millar JK, Korth C, Sive H, Singh KK, Sawa A: Understanding the role of DISC1 in psychiatric disease and during normal development. JNeurosci. 2009 Oct 14;29(41):12768–75.
Free Full Text: http://www.jneurosci.org/content/29/41/12768.long
Genomics

Caballero A,Ugidos A,Liu B,Öling D,Kvint K,Hao X,Mignat C, Nachin L,Molin M,Nyström T: Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing. Mol Cell 2011 May 6;42(3):390–400.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21549315
Aging, neuroplasticity

Chuang DM, Leng Y, Marinova Z, Kim HJ and Chiu CT. Multiple roles of HDAC inhibition in neurodegenerative conditions. Trends in Neurosciences 32:591 601, 2009
http://www.sciencedirect.com/science?_ob=ArticleListURL&_method=list&_ArticleListID=1786097870&_sort=r&_st=13&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=dd97f3dbf55a814ddb5ff3b150b0aa6e&searchtype=a&view=f
Alzheimer’s Disease, bipolar disorder, glutamate, histone deacetylase, neuroprotection, Parkinson’s disease, stroke, valproic acid
HDAC inhibitor valproic acid protects against excitotoxicity in cultured primary neurons induced by exposure to glutamate, Bipolar disorder, classical mitochondrial disorders and Alzheimer’s, Parkinson’s, Stroke are potentially treatable by enhancing mitochondrial vigor with HDAC’s

Do KQ, Cabungcal JH, Frank A, Steullet P, Cuenod M: Redox dysregulation, neurodevelopment, and schizophrenia. Curr Opin Neurobiol. 2009 Apr;19(2):220–30.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19481443
Oxidative phosphorylation, schizophrenia

Du H,Guo L et al. Early deficits in synaptic mitochondria in an Alzheimer’s disease mouse model.Proc Natl Acad Sci USA (2010) Oct. 26, 107 (43): 18670-5.
Free Full text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972922/
Alzheimer’s Disease, synaptic transmission

Du J, Wang Y, Hunter R, Wei Y, Blumenthal R, Falke C, Khairova R, Zhou R, Yuan P, Machado-Vieira R, McEwen BS, Manji HK: Dynamic regulation of mitochondrial function by glucocorticoids. PNAS 2009 Mar 3;106(9):3543–8.
Free Full text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637276/
Synaptic strength, neuroplasticity, glucocorticoids

Durieux J,Wolff J,Dillin A:The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell 2011 Jan 7;144(1):79–91.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21215371
Aging, oxidative phosophorylation

Giulivi C, Zhang Y-F, Omanska-Klusek A, Ross-Inta C, Wong S, Hertz-Picciotto I, Tassone F, Pessah IN: Mitochondrial dysfunction in autism. JAMA 2010 Dec 1;304(21):2389-96.
Free Full Text: http://jama.ama-assn.org/content/304/21/2389.long
Autism, neuronal development

Glorioso C, Oh S, Douillard GG, Sibille E: Brain molecular aging, promotion of neurological disease and modulation by Sirtuin5 longevity gene polymorphism. Neurobiol Dis. 2011 Feb;41(2):279–290. Epub 2010 Sep 29.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20887790
Aging, neurology, genomics, sirtuin 5

Glorioso C, Sibille E: Between destiny and disease: genetics and molecular pathways of human central nervous system aging. Prog Neurobiol. 2011 Feb;93(2):165-81. Epub 2010 Dec 2.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21130140
Aging

Grossman I, Lutz MW, Crenshaw DG, Saunders AM, Burns DK, Roses AD: Alzheimer’s disease: diagnostics, prognostics and the road to prevention. EPMA J. 2010 Jun;1(2):293–303.
Free Full text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987528/?tool=pubmed
Alzheimer, oxidative phosphorylation

Hirai K, Aliev G et al. Mitochondrial Abnormalities in Alzheimer’s Disease. The Journal of Neuroscience (2001) 21 (9): 3017-3023.
Free Full Text: http://www.jneurosci.org/content/21/9/3017.long
Alzheimer’s Disease

Innocenti P, Morrow EH, Dowling DK: Experimental evidence supports a sex-specific selective sieve in mitochondrial genome evolution. Science 2011 May 13;332:845-8.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21566193
Mt RNA, mt DNA, heritability

Iwamoto K, Bundo M, Kato T: Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis. Hum Mol Genet. 2005 Jan 15;14(2):241–53. Epub 2004 Nov 24.
Free Full text: http://hmg.oxfordjournals.org/content/14/2/241.long
Bipolar disorder, schizophrenia, genomics

Jazwinski SM: The retrograde response links metabolism with stress responses, chromatin-dependent gene activation, and genome stability in yeast aging. Gene 2005 Jul 18;354:22–7.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/15890475
Aging, epigenetics, oxidative phosphorylation, yeast

Jazwinski SM: Yeast longevity and aging—the mitochondrial connection. Mech Ageing Dev. 2005 Feb;126(2):243–8.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/15621203
Aging, neurophasticity

Joels M, et al. Acute stress increases calcium current amplitude in rat hippocampus: temporal changes in physiology and gene expression. Eur J Neurosci. 18:1315, 2003
Free Full Text: http://onlinelibrary.wiley.com/doi/10.1046/j.1460-9568.2003.02845.x/full
Neuroprotection

Kapogiannis D, Mattson MP. Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer’s disease. Lancet Neurol2011 (10): 187-98.
Free Full text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026092/
Alzheimer, oxidative phosphorylation, cognition, circuit

Kato T et al. Mechanisms of altered Ca2+ signalling in transformed lymphoblastoid cells from patients with bipolar disorder. Int J Neuropsych 6:379, 2003
Abstract: http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=190573&fulltextType=RA&fileId=S1461145703003717
Calcium, glutamate, lithium, valproic acid

Kelly DP: Aging theories unified. Nature 2011 Feb 17;470(7334):342-3. Epub 2011 Feb 14.
Abstract: http://www.nature.com/nature/journal/v470/n7334/full/nature09896.html
Aging

Konradi et al. Arch 42% of genes reduced in BD brains coded for mitochondrial proteins. Gen Psychiat 61:300, 2004
Abstract: http://archpsyc.ama-assn.org/cgi/content/abstract/61/3/300
Bipolar disorder, gene, mithchondrial proteins

Kudin AP,Kudina TA, Seyfried J, Vielhaber S, Beck H,Elgerand CE Wolfram, Kunz S. Seizure-dependent modulation of mitochondrial oxidative phosphorylation in rat hippocampus. Eur J Neurosci. 2002 Apr;15(7):1105-14
Free Full Text: http://onlinelibrary.wiley.com/doi/10.1046/j.1460-9568.2002.01947.x/abstract;jsessionid=6C6A0FDC1526A5760D15F90DB97EDA03.d02t04
Oxidative phosphorylation, schizophrenia

Lakatos A. Derbeneva O. Younes D. Keator D. Bakken T. Lvova M. Brandon M. Guffanti G. Reglodi D. Saykin A. Weiner M. Macciardi F. Schork N. Wallace DC. Potkin SG. Alzheimer’s Disease Neuroimaging Initiative. Association between mitochondrial DNA variations and Alzheimer’s disease in the ADNI cohort.  Neurobiology of Aging. 31(8):1355-63, 2010
Abstract: http://www.sciencedirect.com/science/article/pii/S019745801000206X
Alzheimer, DNA, brain imaging

Larsen F J. , Schiffer TA. et al. Dietary Inorganic Nitrate Improves Mitochondrial Efficiency in Humans. Cell Metabolism 13 (2011) 149-159.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21284982
Oxidative stress, nitrates

Lavu S, Boss O, Eliott PJ, Lambert PD: Sirtuins—novel therapeutic targets to treat age-associated diseases. Nat Rev Drug Discov. 2008 Oct;7(10):841-53. Erratum in: Nat Rev Drug Discov. 2009 Jun;(8(6):516.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18827827
Aging

Lee J, Kim C, Simon DK, Aminova LR, Andreyev AY, Kushnareva YE, Murphy AN, Lonze BE, Kim K, Ginty DD, Ferrante RJ, Ryu H, and Ratan RR. Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. J Biol Chem. 2005 Dec 9;280(49):40398-401
Free Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612541/
Neuroplasticity, genomics, CREB

Leng, Y. et al. Lithium and VPA provide synergistic neuroprotective effects of in aging CGC cultures. J. Neurosci. 2008;28:2576-2588.
Abstract: http://www.jneurosci.org/content/28/10/2576.abstract?sid=1ab7710e-30b4-46d0-9456-00cf2ec1cbfa
lithium, neuroprotection, valproic acid, Alzheimer’s Diseaes, genomics, mitochondrial membrane 2

Lutz MW, Crenshaw DG, Saunders AM, Roses AD: Genetic variation at a single locus and age of onset for Alzheimer’s disease. Alzheimers Dement. 2010 Mar;6(2):125–31.
Free Full text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874876/
Aging, Alzheimer’s disease

Mancuso M, Calsolaro V, Orsucci D et al. Mitochondria, Cognitive Impairment, and Alzheimer’s Disease.Inter Jour Alzh Disease. (2009) July 6, 8 pages.
Free Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925259/
Alzheimer’s Disease, cognition

McFarland R, Taylor RW, Turnbull DM. A neurological perspective on mitochondrial disease. Lancet Neurol. (2010);9: 829-40.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20650404
Neurology, oxidative phosphorylation

McMahon F et al Am J Hum. Patterns of maternal transmission in bipolar affective disorder. Genet 56:1277, 1995
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/7762550?dopt=Abstract
mtDNA, oxidative phosphorylation
Function occurs via maternal transmission. Only organelle containing non-nuclear genetic information, consequent to female gamete containing more cytoplasm than male. mtDNA encodes polypeptides essential in oxidative phosphorylation Excess of affected maternal relatives vs male relatives positive for BD (27% vs 14%, P=.004, with 2.3 to 2.8-fold increased risk in offspring of affected mothers.
Mitochondria is only organelle containing non-nuclear genetic information, consequent to female gamete containing more cytoplasm than male. mtDNA encodes polypeptides essential in oxidative phosphorylation . Excess of affected maternal relatives vs male relatives positive for BD (27% vs 14%, P=.004, with 2.3 to 2.8-fold increased risk in offspring of affected mothers.

Navarro A and Boveris A. Brain mitochondrial dysfunction in aging, neurodegeneration, and Parkinson’s disease. Front Aging Neurosci.2010 Sep 1;2. pii: 34
Free Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947925/
Alzheimer’s Disease, Parkinson’s Disease, neuroplasticity

Nunomura A, Perry G, Aliev G et al. Oxidative Damage is the Earliest Event in Alzheimer Disease. J Neuropathol Exp Neurol.(2001) Aug; 60 (8): 759-67.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/11487050
Alzheimer’s Disease, oxidative stress

Perova T, Kwan M, Li PP, Warsh JJ. Differential modulation of intracellular Ca2+ responses in B lymphoblasts by mood stabilizers. International Journal of Neuropsychopharmacology (2010), 13, 693–702
Abstract: http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=7819873&fulltextType=RA&fileId=S1461145709000261
bipolar disorder, calcium, lymphoblast, valproate, lithium

Prabakaran S, Swatton JE, Ryan MM, Huffaker SJ, Huang JT, Griffin JL, Wayland M, Freeman T, Dudbridge F, Lilley KS, Karp NA, Hester S, Tkachev D, Mimmack ML, Yolken RH, Webster MJ, Torrey EF, Bahn S: Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress. Mol. Psychiatry 2004 Jul;9(7):684–97, 643.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/15098003
Schizophrenia, oxidative stress

Quiroz JA1, Gray NA Kato T, Manji HK. Mitochondrially Mediated Plasticity in the Pathophysiology and Treatment of Bipolar Disorder. Neuropsychopharmacology 33, 2551–2565, 2008
Abstract: http://www.nature.com/npp/journal/v33/n11/abs/1301671a.html
bipolar disorder; mitochondria; synaptic plasticity; bcl-2; lithium; calcium regulation

Reddy PH , Beal MF. Are mitochondria critical in the pathogenesis of Alzheimer’s disease? Brain Research Reviews. 49 (2005) : 618-632.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/16269322
Alzheimer’s Disease

Roses AD: An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer Disease. Arch Neurol.2010 May;67(5):536-41.
Free Full Text: http://archneur.ama-assn.org/cgi/content/full/67/5/536
Genomics, Alzheimer’s Disease

Roses AD, Lutz MW, Amrine-Madsen H, Saunders AM, Crenshaw DG, Sundseth SS, Huentelman MJ, Welsh-Bohmer KA, Reiman EM: A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer’s disease. Pharmacogenomics J. 2010 Oct;10(5):375–84. Epub 2009 Dec 22.
Free Full text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946560/
Alzheimer’s disease, genomics, TOMM40

Rossignol DA,Frye RE. Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis. Mol Psychiatry (2011) Jan. 25.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21263444
Autism

Sahin E, Colia S, Liesa M et al. Telomere dysfunction induces metabolic and mitochondrial compromise. (2011) Nature 470 (7334): 359-365.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21307849
Genomics

Srinivasan V, Kriete A, Sacan A, Jazwinski SM: Comparing the yeast retrograde response and NF-?B stress responses: implications for aging. Aging Cell 2010 Dec;9(6):933–41. Epub 2010 Oct 21.
Free Full text: http://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2010.00622.x/abstract;jsessionid=B4A083A8FF0FE7D601F7FC179ED5D2CF.d02t01
Aging, oxidative stress

Srinivasan V, Spence DW, Pandi-Perumal SR, Brown GM, Cardinali DP: Melatonin in mitochondrial dysfunction and related disorders. Int J Alzheimers Dis. 2011:326320. Epub 2011 May 4.
Free Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100547/?tool=pubmed
Aging, melatonin

Su B, Wang X, Bonda D, Perry G, Smith M, Zhu X. Abnormal Mitochondrial Dynamics – A Novel Therapeutic Target for Alzheimer’s Disease.Mol Neurobiol. (2010) 41: 87-96.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20101529
Alzheimer’s Disease, oxidative stress

Wallace DC. Colloquium paper: bioenergetics, the origins of complexity, and the ascent of man. Proceedings of the National Academy of Sciences of the United States of America. 107 Suppl 2:8947-53, 2010
Abstract: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024017/
Genomics, oxidative phosphorylation

Wallace DC. Bioenergetics and the epigenome: interface between the environment and genes in common diseases. [Review] Developmental Disabilities Research Reviews. 16(2):114-9, 2010
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20818725
Genomics, oxidative phosphorylation

Wang X, Su B, Lee H et al. Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer’s Disease.The Journal of Neuroscience (2009) 29 (28): 9090-9103.
Free Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735241/
Alzheimer’s Disease

Yang W, Hekimi S: A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans. PLoS Biol. 2010 Dec 7;8(12):e1000556. doi:10.1371/journal.pbio.1000556
Free Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998438/
Aging, oxidative stress

Zhou R, Yazdi AS, Menu P, Tschopp J: A role for mitochondria in NLRP3 inflammasome activation. Nature 2011 Jan 13;469(7329):221-5. Epub 2010 Dec 1.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21124315
Inflammation