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Synergy in Action

13th Annual Scientific Meeting

21 – 23 February, 2017   //   The Fairmont, Washington DC

Distinguished Poster Award Recipient:

Estimating Treatment Effect Heterogeneity in Cognitive Training Programs (Khan)

All Poster PDFs and Abstracts are available at the end of the second day.

Day 1 (21 February 2017)

Presidential Welcome S Marder
slides
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 video
Advantages and Challenges of Adaptive CNS Trials: Real World Lessons Chairs:
R Marcus
J Kando
  Introduction/Brief update R Marcus
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 video
  Adaptive Population Enrichment Design: Drug Development Efficacy in Rare Epileptic Symptoms J Segieth
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 video
  Adaptive Design Comparative Effectiveness in Status Epilepticus K Broglio
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 video
  Identification of Meaningful Cognitive Endpoints in Studies of Pharmacological Therapies for Cognitive Impairment in Schizophrenia M Sand
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 video
  Layers of an Onion: Considerations for a Confirmatory, Adaptive CNS Trial B Millen
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  Update from FDA Statistician on Adaptive Design Methodology H M Hung*
  Panel Discussion Speakers
 
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Working Group Dinners

 
  Abuse Liability: A Lethal Combination: Clinical Trial Design Considerations to Elevate the Nature of Opioid and Benzodiazepine Interactions Chairs:
B Setnik
M Sokolowska
M Klein
Working Group Slides:
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  Behavioral and Psychiatric Symptoms in Dementia Chairs:
L Ereshefsky
D Miller
L Pani
Working Group Summary:
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  Prevention Trials of Alzheimer’s Disease- Ongoing Optimization and the Roles of Biomarkers and Cognitive, Performance, and Functional Assessments Chairs:
H Posner
P Harvey
Working Group Slides:
Arrighi
Beckett
Bilgel
  Cognitive Dysfunction Chairs:
J Parker
M Fava
Working Group Slides:
slides slides
  Methodological Challenges in International CNS Clinical Trials Chairs:
A Kalali
E Pappadopulos
Working Group Slides:
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  Missing Data Chairs:
P Lim
N Samad
Working Group Slides:
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  Negative Symptoms Chairs:
S Marder
D Daniel
Working Group Slides:
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  Mitigating Nonadherence Chairs:
T Shiovitz
D McCann
Working Group Slides:
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Day 2 (22 February 2017)

Optimizing Use of ‘Big Data’ for Patient Identification and Disease Management: Seperating Signal from Noise- Part 1 Chairs:
L Alphs
G Wittenberg
  Introduction L Alphs
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  The ‘Big Data’ Transformation of Drug Development: From Promise to Practice G Wittenberg
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  Generating Reliable Evidence from Real-World Data: Lessons from the Observational Health Data Sciences and Informatics (OHDSI) P Ryan
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  A Model of Virtual Learning Health System for Mood Disorders P Zandi
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  Harnessing Mobile and Sensor Technology to Help Patients with Diseases of the Brain and Central Nervous System V Narayan
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  ADNI as a Model of ‘Big Data’ Collaboration S Potkin
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  Data Linkage Methods and Challenges A Kress
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  Panel Discussion  Speakers
Optimizing Use of ‘Big Data’ for Patient Identification and Disease Management: Seperating Signal from Noise- Part 2 Chairs:
L Alphs

G Wittenberg
  Review of Morning Session L Alphs
  Challenges/Opportunities in the use of ‘Big Data’ for the FDA B Temple
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  Regulatory Opportunities and Challenges in Europe: From Registries to PRIority MEdicines (PRIME) and Return L Pani
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  Optimizing Use of ‘Big Data’ for Patient Identification and Disease Management—An Example from the Department of Veterans Affairs R Bossarte*

  Challenges/Opportunities in the Use of ‘Big Data’ in Health Care Services Setting (pharmacy/insurer) A Contreras
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  Public Policy Around ‘Big Data’ A Basu
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  Panel Discussion and Open Discussion L Alphs
Speakers
  Summary G Wittenberg
  Poster Session/Reception Poster PDFs and Abstracts

Day 3 (23 February 2017)

  Presentation of the Andrew C. Leon Distinguished Career Award S Marder
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L Alphs
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Silver Linings Playbook: The Positive Side of Negative Trials Chairs:
R Keefe
S Romano
   Introduction R Keefe
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  “The Set-Up”: Skimping on the Fundamentals Can Lead to Failure S Romano
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  Failures of Translation in Stroke and Cerebrovascular Disease: What Can Be Learned? D Laskowitz
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  The Difficulties in Going from P2 To P3 in CNS Trials: Red Flags from a Recent CIS Program S Brannan
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  How Molecules that Fail can Influence Future Research:
Semagacestat and BACE Inhibitors
R Mohs
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  A New PANSS Factor Analysis Intended to Reduce Pseudospecificity Among Domains and Enhance Understanding of Symptom Change in Antipsychotic-Treated Patients with Schizophrenia T Loebel/
S Hopkins*
  Panel and Regulatory Discussion R Keefe
T Laughren
L Pani
  Meeting Adjourned
S Marder
  *Presentation not released